Drug Interactions With Amoxicillin and Clavulanate Potassium

Oral Anticoagulants
There have been rare reports of amoxicillin and clavulanate potassium interacting with oral anticoagulants such as warfarin, causing a high international normalized ratio (INR), which may indicate an increased risk for bleeding. Your healthcare provider may need to monitor you more closely if you must take these two medications together.
 
Oral Contraceptives
Despite the longstanding belief that antibiotics interact with birth control pills, several studies have shown that almost all antibiotics do not increase the risk of pregnancy in women taking birth control pills. Nevertheless, there have been reports of birth control pill failure in women who have taken antibiotics. Ask your healthcare provider about whether you need a backup method of birth control while taking amoxicillin and clavulanate potassium.
 
Oral Typhoid Vaccine
Amoxicillin and clavulanate potassium may decrease the effectiveness of the oral typhoid vaccine. If you have taken the antibiotic recently or are currently taking it, your oral typhoid vaccine may need to be postponed for at least a day after taking amoxicillin and clavulanate potassium.
 
Probenecid
Probenecid can decrease the body's ability to remove amoxicillin and clavulanate potassium from the blood, potentially leading to high amoxicillin and clavulanate potassium blood levels. Talk with your healthcare provider before taking these medications together.
 

Final Thoughts on Drug Interactions With Amoxicillin and Clavulanate Potassium

It is possible that not all drug interactions with amoxicillin and clavulanate potassium were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any drug interactions that may apply to you.
 
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