Drug Interactions With Amoxicillin and Clavulanate Potassium

Allopurinol, methotrexate, and oral contraceptives may cause negative drug interactions with amoxicillin and clavulanate potassium. When these interactions occur, the effectiveness of the medications may decrease and your risk for side effects may increase. Be sure to tell your healthcare provider about all other medicines you are taking to help prevent drug interactions with amoxicillin and clavulanate potassium.

Drug Interactions With Amoxicillin and Clavulanate Potassium: An Overview 

Amoxicillin and clavulanate potassium (Augmentin®) can potentially interact with several other medicines. Some of thee medicines that may lead to amoxicillin and clavulanate potassium drug interactions include:
 

More Information on Amoxicillin and Clavulanate Potassium Interactions

The following sections explain in detail the potentially negative interactions that can occur when amoxicillin and clavulanate potassium is combined with any of the drugs listed above.
 
Allopurinol
Combining allopurinol with antibiotics similar to amoxicillin and clavulanate potassium increases the risk of skin rashes. It is not known whether this is also true with amoxicillin and clavulanate potassium.
 
Methotrexate
Penicillin-type antibiotics (including amoxicillin and clavulanate potassium) may decrease the body's ability to remove methotrexate, leading to high blood levels of it. Your healthcare provider may need to monitor you more closely to prevent this interaction from occurring.

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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