Drug Interactions With Amoxicillin and Clavulanate Potassium
Allopurinol, methotrexate, and oral contraceptives may cause negative drug interactions with amoxicillin and clavulanate potassium. When these interactions occur, the effectiveness of the medications may decrease and your risk for side effects may increase. Be sure to tell your healthcare provider about all other medicines you are taking to help prevent drug interactions with amoxicillin and clavulanate potassium.
Amoxicillin and clavulanate potassium (Augmentin®) can potentially interact with several other medicines. Some of thee medicines that may lead to amoxicillin and clavulanate potassium drug interactions include:
- Allopurinol (Aloprim™, Zyloprim®)
- Methotrexate (Rheumatrex®, Trexall™)
- Oral anticoagulants (“blood thinners”), such as warfarin (Coumadin®, Jantoven®)
- Oral contraceptives (birth control pills)
- Oral typhoid vaccine
- Probenecid (Benuryl™).
The following sections explain in detail the potentially negative interactions that can occur when amoxicillin and clavulanate potassium is combined with any of the drugs listed above.
Combining allopurinol with antibiotics similar to amoxicillin and clavulanate potassium increases the risk of skin rashes. It is not known whether this is also true with amoxicillin and clavulanate potassium.
Penicillin-type antibiotics (including amoxicillin and clavulanate potassium) may decrease the body's ability to remove methotrexate, leading to high blood levels of it. Your healthcare provider may need to monitor you more closely to prevent this interaction from occurring.