Drug Interactions With Amoxicillin ER

Allopurinol
Combining allopurinol with amoxicillin ER increases the risk of skin rashes or other allergic reactions. Check with your healthcare provider before taking these medications together.
 
Birth Control Pills
Despite the longstanding belief that antibiotics interact with birth control pills, several studies have shown that most antibiotics do not increase the risk of pregnancy in women taking birth control pills. Nevertheless, there have been reports of birth control pill failure in women who have taken antibiotics. Ask your healthcare provider about whether you need a backup method of birth control. In many situations, it is better to use backup than to take any risk of an unintended pregnancy.
 
Certain Other Antibiotics
Theoretically, certain other antibiotics can make amoxicillin ER less effective. Check with your healthcare provider before taking such medications together.
 
Methotrexate
Penicillin-type antibiotics (including amoxicillin ER) may decrease the body's ability to remove methotrexate, leading to high blood levels of this medication. Your healthcare provider may need to monitor you more closely in case this drug interaction occurs.
 
Oral Typhoid Vaccine
Amoxicillin ER may decrease the effectiveness of the oral typhoid vaccine. If you have taken amoxicillin ER recently or are currently taking it, your oral typhoid vaccine may need to be postponed for at least a day after taking the antibiotic.
 
Probenecid
Probenecid can decrease the body's ability to remove amoxicillin ER from the blood, potentially leading to high blood levels of the antibiotic. Talk with your healthcare provider before taking these medications together.
 
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Amoxicillin ER Drug Information

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