Precautions and Warnings With Amoxicillin ER

There are several precautions and warnings with amoxicillin ER to be aware of before starting treatment. For instance, if you have kidney disease or certain other health problems, you may not be able to safely use this drug. Safety concerns also extend to people with certain allergies (including a penicillin allergy) and to women who are pregnant or breastfeeding.

What Should I Tell My Healthcare Provider Before Taking Amoxicillin ER?

You should talk with your healthcare provider prior to taking amoxicillin ER (Moxatag™) if you have:
  • Kidney disease, such as kidney failure (renal failure)
  • A penicillin allergy
  • Any other allergies, including allergies to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medicines you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Amoxicillin ER Warnings and Precautions

Some warnings and precautions to be aware of with amoxicillin ER include the following:
  • Let your healthcare provider know if you experience bloody or watery diarrhea. While diarrhea is a common side effect of amoxicillin ER, bloody or watery diarrhea may be a sign of a serious reaction to the drug that can occur when certain bacteria (Clostridium difficile) overgrow in the colon. This severe reaction can occur long after you stop taking this antibiotic and can lead to life-threatening complications.
  • The active ingredient in amoxicillin ER belongs to the penicillin group of antibiotics. You should not take this medicine if you are allergic to penicillin. Let your healthcare provider know immediately if you notice any signs of an allergic reaction, such as a rash, itching, hives, wheezing, swelling of the mouth or lips, or difficulty breathing. An allergic reaction to this drug can be dangerous.
  • Sometimes, antibiotics can cause yeast infections, as they can get rid of "good" bacteria that help protect against such infections. Let your healthcare provider know if you develop a vaginal yeast infection or thrush (a yeast infection of the mouth) while taking amoxicillin ER.
  • This medication is not recommended for people with severe kidney disease.
  • Amoxicillin ER should not be used to treat viruses, such as the common cold or the flu. The medicine is completely ineffective for treating viruses, and such use can lead to bacterial resistance.
  • It is very important that you take amoxicillin ER exactly as prescribed. Skipping doses or stopping treatment too early (even if you feel better) can lead to bacterial resistance.
  • In general, people with a mononucleosis infection ("mono") should not take this drug, as doing so increases the risk of developing a rash.
  • Amoxicillin ER can interact with other medications (see Drug Interactions With Amoxicillin ER).
  • Amoxicillin ER is considered a pregnancy Category B medication. This means that it is probably safe for use during pregnancy, although the full risks are not known. Talk to your healthcare provider about the risks and benefits of taking this drug when pregnant (see Amoxicillin and Pregnancy for more information).
  • Amoxicillin ER passes through breast milk. Therefore, if you are breastfeeding or plan to start, be sure to talk with your healthcare provider before taking this medication (see Amoxicillin and Breastfeeding for more information).
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Amoxicillin ER Drug Information

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