Drug Interactions With Aztreonam Injection

A few medicines can potentially lead to drug interactions with aztreonam injection, including certain antibiotics, some bowel prep medications, and the typhoid vaccine. Some of these reactions can alter the levels of the drugs in your blood, decreasing the effectiveness of the medications or increasing your risk of side effects. You should talk with your pharmacist or healthcare provider about any interactions that may apply to you.

An Overview of Aztreonam Injection Interactions

Aztreonam injection (Azactam®) may interact with a few other medications. Some of the medicines that may lead to drug interactions with this product include but are not limited to:
 
  • Aminoglycoside antibiotics, such as:
    • Amikacin (Amikin®)
    • Gentamicin
    • Kanamycin (Kantrex®)
    • Neomycin (Neo-Fradin®)
    • Streptomycin
    • Tobramycin
   

More Detail on Drug Interactions With Aztreonam Injection

The following sections explain in detail the potentially negative reactions that can occur when any of the drugs mentioned above are combined with aztreonam injection.
 
Aminoglycoside Antibiotics
If you use aztreonam injection with an aminoglycoside antibiotic, your healthcare provider may choose to monitor your kidney function more closely. This is because aminoglycoside antibiotics can cause kidney problems, and you may need a lower aztreonam injection dosage if your kidneys do not work as well.
 
Furosemide
Furosemide may increase blood levels of aztreonam injection, possibly increasing your risk for aztreonam injection side effects. Talk to your healthcare provider about this potential interaction before using these medications together.
 
Probenecid
Probenecid may increase blood levels of aztreonam injection, possibly increasing your risk for aztreonam injection side effects. Talk to your healthcare provider about this potential interaction before using these medications together.
 
Sodium Picosulfate/Magnesium Oxide/Anhydrous Citric acid
Sodium picosulfate/magnesium oxide/anhydrous citric acid is a medicine used to empty the bowels before a colonoscopy (this is known as bowel prep). The manufacturer of the medicine recommends that it not be used in combination with antibiotics, as antibiotics may decrease its effectiveness. Your healthcare provider may recommend a different bowel prep medication if you need a colonoscopy during aztreonam injection treatment.
 
Tice BCG
Tice BCG is a medication used to treat and prevent certain types of bladder cancer. The manufacturer of Tice BCG recommends that it not be used in combination with antibiotics, as antibiotics may decrease its effectiveness. Talk to your healthcare provider about this potential interaction if you will be using these medications together.
 
Typhoid Vaccine
Antibiotic medicines, such as aztreonam injection, may decrease the effectiveness of the typhoid vaccine. This interaction is only a potential concern with the live vaccine, which is taken by mouth. Talk to your healthcare provider about this potential interaction. If you will be receiving the live typhoid vaccine, your healthcare provider may recommend you wait until you have completed aztreonam injection treatment.  
 

Aztreonam Injection Information

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