Drug Interactions With Cefixime

Taking birth control pills, the oral typhoid vaccine, or certain other drugs in combination with cefixime may lead to a decreased effectiveness of the products, dangerous side effects, or other problems. Your healthcare provider will ask you about all other vitamins, supplements, or prescription or nonprescription medications you are taking to help minimize adverse interactions with cefixime.

An Overview of Cefixime Interactions

Cefixime (Suprax®) may interact with a few other products. Some of the drugs that can react with cefixime include but are not limited to:
  • Aminoglycoside antibiotics, such as:
    • Amikacin (Amikin®)
    • Gentamicin
    • Kanamycin (Kantrex®)
    • Neomycin (Neo-Fradin®)
    • Streptomycin
    • Tobramycin

More Detail on Drug Interactions With Cefixime

The following sections explain in detail the potentially negative reactions that can occur when cefixime is combined with any of the drugs listed above.
Aminoglycoside Antibiotics
Combining cefixime with an aminoglycoside antibiotic may increase the risk of kidney damage. Nonetheless, in some very serious situations, such combinations may be used when the possible benefits outweigh the likely risks.
Birth Control Pills
Despite the long-standing belief that antibiotics interact with birth control pills, several studies have shown that most antibiotics do not increase the risk of pregnancy in women taking birth control pills. Nevertheless, there have been reports of birth control pill failure in women who have taken antibiotics.
Ask your healthcare provider about whether you need to use a backup method of birth control while taking cefixime (see Antibiotics and Birth Control Pills for more information). If it is very important to you to avoid pregnancy, you might consider using a backup method just to be safe.
There have been reports that cefixime may increase the levels of carbamazepine in the blood. Your healthcare provider may want to monitor your carbamazepine levels, or might decide to prescribe a different antibiotic.
Oral Typhoid Vaccine
Like other antibiotics, cefixime may decrease the effectiveness of the oral typhoid vaccine. If you have taken cefixime recently or are currently taking it, your oral typhoid vaccine may need to be postponed for at least a day after taking the drug.
Probenecid can decrease the body's ability to remove cefixime from the blood, potentially leading to high cefixime blood levels. Talk with your healthcare provider before taking these medications together.
Cefixime may increase the risk of bleeding with warfarin. If these medications must be taken together, it would be a good idea for your healthcare provider to monitor your PT/INR to avoid any dangerous bleeding.
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