Precautions and Warnings With Cefixime

By reviewing the safety precautions and warnings with cefixime, you may be able to avoid potentially serious problems like drug interactions and allergic reactions. Also, people with kidney problems may not be able to safely use this antibiotic or may need a lower dosage. It is also important to be aware of potentially dangerous side effects, such as watery or bloody diarrhea, which require immediate medical care.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking cefixime (Suprax®) if you have:
  • Kidney disease, such as kidney failure (renal failure)
  • Liver disease, such as hepatitis, cirrhosis, or liver failure
  • An allergy to cephalosporin or penicillin antibiotics
  • Any other allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Cefixime Precautions and Warnings

Some warnings and precautions to be aware of prior to taking this medication include the following:
  • Cefixime contains an antibiotic that belongs to the cephalosporin group of antibiotics, which are related to penicillin antibiotics. Some people who are allergic to penicillin will also be allergic to cefixime. An allergic reaction can be quite dangerous.
Let your healthcare provider know immediately if you notice any signs of an allergic reaction, such as:  
    • A rash
    • Itching
    • Hives
    • Wheezing
    • Swelling of the mouth or lips
    • Difficulty breathing.
  • Make sure your healthcare provider knows if you have kidney disease, as the kidneys remove cefixime from the body. If your kidneys are not functioning well, you will need a lower and/or less-frequent dosage.
  • Let your healthcare provider know if you experience bloody or watery diarrhea. While diarrhea is a common side effect of cefixime, bloody or watery diarrhea may be a sign of a serious reaction that can occur when certain bacteria (Clostridium difficile) overgrow in the colon. This severe reaction can occur long after you stop using the drug and can be life-threatening.
  • Antibiotics, including cefixime, can sometimes cause yeast infections, as they can get rid of "good" bacteria that help protect against yeast infections. Let your healthcare provider know if you develop a vaginal yeast infection or thrush (a yeast infection of the mouth) during treatment.
  • Cefixime should not be used to treat viruses, such as the common cold or the flu. This drug is completely ineffective for treating viruses, and such use can lead to bacterial resistance.
  • Cefixime can impair the body's ability to form blood clots, especially in people who are already at risk for bleeding, including people with liver or kidney disease or people taking "blood thinners" (anticoagulants).
  • Cefixime is a pregnancy Category B medication. This means that it is probably safe for use during pregnancy, although the full risks are currently unknown. Talk to your healthcare provider about the risks and benefits of taking this medicine during pregnancy (see Suprax and Pregnancy for more information).
  • It is unknown if cefixime passes through breast milk. Therefore, if you are breastfeeding or plan to start, talk with your healthcare provider prior to taking cefixime (see Suprax and Breastfeeding for more information).
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Cefixime Antibiotic Information

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