Drug Interactions With Cefpodoxime
The following sections explain in detail the potentially negative interactions that can occur when cefpodoxime is combined with any of the drugs listed above.
Combining cefpodoxime with an aminoglycoside antibiotic may increase the risk of kidney damage. Nonetheless, in some very serious situations, this combination may be used when the possible benefits outweigh the likely risks.
High doses of antacids have been shown to significantly decrease the absorption of cefpodoxime, making it less effective. It is best to separate cefpodoxime and antacids by at least two hours.
Birth Control Pills
Despite the long-standing belief that antibiotics interact with birth control pills, several studies have shown that most antibiotics do not increase the risk of pregnancy in women taking birth control pills. Nevertheless, there have been reports of birth control pill failure in women who have taken antibiotics.
Ask your healthcare provider about whether you need to use a backup method of birth control while taking cefpodoxime (see Antibiotics and Birth Control Pills for more information). If it is very important to you to avoid pregnancy, you might consider using a backup method just to be safe.
H2 blockers have been shown to significantly decrease the absorption of cefpodoxime, making it less effective. It is best to separate cefpodoxime and H2 blockers by at least two hours.
Oral Typhoid Vaccine
Like other antibiotics, cefpodoxime may decrease the effectiveness of the oral typhoid vaccine. If you have taken cefpodoxime recently or are currently taking it, your oral typhoid vaccine may need to be postponed for at least a day after taking the drug.
Probenecid can decrease the body's ability to remove cefpodoxime from the blood, potentially leading to high cefpodoxime blood levels. Talk with your healthcare provider before taking these medications together.
No interactions between PPIs and cefpodoxime have been identified. However, because other acid-reducing medications, such as antacids or H2 blockers, have been shown to reduce the absorption of cefpodoxime, it is logical to assume that the same might be true of PPIs.
It is unknown how exactly to handle this potential interaction. Separating the doses may not be effective at preventing the drug interaction, as PPIs lower stomach acid for a long time.