Precautions and Warnings With Cefpodoxime

A number of safety precautions and warnings are associated with cefpodoxime, which can help minimize your risk for developing allergic reactions, drug interactions, or other potentially dangerous complications. Other potential dangers may apply to women who are pregnant or breastfeeding, as well as to people who have problems with their kidneys or liver.

 

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking cefpodoxime proxetil (Vantin®) if you have:
 
  • Kidney disease, such as kidney failure (renal failure)
  • Liver disease, such as hepatitis, cirrhosis, or liver failure
  • An allergy to cephalosporin or penicillin antibiotics
  • Any other allergies, including to foods, dyes, or preservatives.
 
In addition, let your healthcare provider know if you are:
 
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
 
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
 

Specific Cefpodoxime Precautions and Warnings

Some warnings and precautions to be aware of prior to using this medication include the following:
 
  • Cefpodoxime contains an antibiotic that belongs to the cephalosporin group of antibiotics, which are related to penicillin antibiotics. Some people who are allergic to penicillin will also be allergic to cefpodoxime. An allergic reaction can be quite dangerous. Let your healthcare provider know immediately if you notice any signs of an allergic reaction, such as:
    • A rash
    • Itching
    • Hives
    • Wheezing
    • Swelling of the mouth or lips
    • Difficulty breathing.
 
  • Make sure your healthcare provider knows if you have kidney disease, as the kidneys remove cefpodoxime from the body. If your kidneys are not functioning well, you will need a lower and/or less frequent dosage.
 
  • Let your healthcare provider know if you experience bloody or watery diarrhea. While diarrhea is a common side effect of cefpodoxime, bloody or watery diarrhea may be a sign of a serious reaction that can occur when certain bacteria (Clostridium difficile) overgrow in the colon. This severe reaction can occur long after you stop using the drug and can be life-threatening.
 
  • Antibiotics, including cefpodoxime, can sometimes cause yeast infections, as they can get rid of "good" bacteria that help protect against yeast infections. Let your healthcare provider know if you develop a vaginal yeast infection or thrush (a yeast infection of the mouth) during treatment.
 
  • Cefpodoxime should not be used to treat viruses, such as the common cold or the flu. This drug is completely ineffective for treating viruses, and such use can lead to bacterial resistance.
   
  • Cefpodoxime is a pregnancy Category B medication. This means that it is probably safe for use during pregnancy, although the full risks are currently unknown. Talk to your healthcare provider about the risks and benefits of using this drug when pregnant (see Vantin and Pregnancy for more information).
 
  • Cefpodoxime passes through breast milk. Therefore, if you are breastfeeding or plan to start, talk with your healthcare provider prior to taking this drug (see Vantin and Breastfeeding for more information).
 
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