Precautions and Warnings With Ceftaroline
Several safety precautions and warnings are associated with ceftaroline, which can help reduce your risk for developing certain complications from this antibiotic. Some of the potential problems include drug interactions, allergic reactions, and neurological problems. Women who are pregnant or breastfeeding should also review potential risks with their healthcare provider prior to using this drug.
What Should I Tell My Healthcare Provider?
- Kidney disease, such as kidney failure (renal failure)
- An allergy to cephalosporin or penicillin antibiotics
- Any other allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
- Pregnant or thinking of becoming pregnant
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
Specific Ceftaroline Precautions and Warnings
Some warnings and precautions to be aware of prior to using this medication include the following:
- Ceftaroline contains an antibiotic that belongs to the cephalosporin group of antibiotics, which are related to penicillin antibiotics. Some people who are allergic to penicillin will also be allergic to ceftaroline. An allergic reaction can be quite dangerous. Let your healthcare provider know immediately if you notice any signs of an allergic reaction, such as:
- A rash
- Swelling of the mouth or lips
- Difficulty breathing.
- Make sure your healthcare provider knows if you have kidney disease, as the kidneys remove ceftaroline from the body. If your kidneys are not functioning well, you will need a lower and/or less frequent dosage.
- Let your healthcare provider know if you experience bloody or watery diarrhea. While diarrhea is a common side effect of ceftaroline, bloody or watery diarrhea may be a sign of a serious reaction that can occur when certain bacteria (Clostridium difficile) overgrow in the colon. This severe reaction can occur long after you stop using the drug and can be life-threatening.
- Antibiotics, including ceftaroline, can sometimes cause yeast infections, as they can get rid of "good" bacteria that help protect against yeast infections. Let your healthcare provider know if you develop a vaginal yeast infection or thrush (a yeast infection of the mouth) during treatment.
- Alert your healthcare provider right away if you develop any neurological symptoms, such as seizures, confusion, hallucinations, or coma. Problems such as these may occur when ceftaroline dosages are too high.
- Ceftaroline should not be used to treat viruses, such as the common cold or the flu. This drug is completely ineffective for treating viruses, and such use can lead to bacterial resistance.
- Cephalosporins can sometimes cause hemolytic anemia, a potentially dangerous problem involving the destruction of red blood cells. Alert your healthcare provider to any symptoms of this problem, such as:
- Pale skin
- A rapid heart rate
- Red- or brown-colored urine.
- Ceftaroline may react with other medications (see Ceftaroline Drug Interactions).
- Ceftaroline is a pregnancy Category B medication. This means that it is probably safe for use during pregnancy, although the full risks are currently unknown. Talk to your healthcare provider about the risks and benefits of using this drug when pregnant (see Teflaro and Pregnancy for more information).
- It is unknown if ceftaroline passes through breast milk. Therefore, if you are breastfeeding or plan to start, talk with your healthcare provider prior to using this medicine (see Teflaro and Breastfeeding for more information).