Drug Interactions With Ceftibuten

Talk to your healthcare provider before taking ceftibuten with certain drugs, such as birth control pills, probenecid, or gentamicin. Combinations such as these may lead to adverse interactions, potentially increasing your risk for serious complications or decreasing the effectiveness of the medications. Talk to your healthcare provider about ways to minimize any potential risks.


An Overview of Ceftibuten Interactions

Ceftibuten (Cedax®) may react with a few other products. Some of the drugs that can interact with ceftibuten include but are not limited to:
  • Aminoglycoside antibiotics, such as:
    • Amikacin (Amikin®)
    • Gentamicin
    • Kanamycin (Kantrex®)
    • Neomycin (Neo-Fradin®)
    • Streptomycin
    • Tobramycin

More Detail on Drug Interactions With Ceftibuten

The following sections explain in detail the potentially negative interactions that can occur when ceftibuten is combined with any of the drugs listed above.
Aminoglycoside Antibiotics
Combining ceftibuten with an aminoglycoside antibiotic may increase the risk of kidney damage. Nonetheless, in some very serious situations, such combinations may be used when the possible benefits outweigh the likely risks.
Birth Control Pills
Despite the long-standing belief that antibiotics interact with birth control pills, several studies have shown that most antibiotics do not increase the risk of pregnancy in women taking birth control pills. Nevertheless, there have been reports of birth control pill failure in women who have taken antibiotics.
Ask your healthcare provider about whether you need to use a backup method of birth control while taking ceftibuten (see Antibiotics and Birth Control Pills for more information). If it is very important to you to avoid pregnancy, you might consider using a backup method just to be safe.
Oral Typhoid Vaccine
Like other antibiotics, ceftibuten may decrease the effectiveness of the oral typhoid vaccine. If you have taken ceftibuten recently or are currently taking it, your oral typhoid vaccine may need to be postponed for at least a day after taking the drug.
Probenecid can decrease the body's ability to remove ceftibuten from the blood, potentially leading to high ceftibuten blood levels. Talk with your healthcare provider before taking these medications together.
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Ceftibuten Drug Information

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