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Ceftriaxone Drug Interactions

Drug interactions with ceftriaxone can cause your body to metabolize the medicines differently than intended. This can sometimes significantly increase the amount of ceftriaxone in your system. Warfarin, probenecid, and sulfinpyrazone are a few of the drugs that can interfere with ceftriaxone. Talk with your healthcare provider or pharmacist about any ceftriaxone drug interactions that may apply to you.

 

Ceftriaxone Drug Interactions: An Introduction

Ceftriaxone (Rocephin®) can interact with a number of medicines. Drugs that can interact with ceftriaxone include, but are not limited to, the following:
 
  • Warfarin (Coumadin®, Jantoven®)
  • Probenecid (Benemid®, Probalan®)
  • Sulfinpyrazone (Anturane®)
  • Calcium or calcium-containing products. 
     
Warfarin (Coumadin, Jantoven)
If you are taking ceftriaxone and warfarin, your body may metabolize the drugs differently than intended. You healthcare provider may choose to monitor your INR and prothrombin time more frequently and adjust accordingly. INR and prothrombin time are tests used to measure how well your blood clots.
 
Probenecid (Benemid, Probalan)
If you are taking both ceftriaxone and probenecid, your body may metabolize the drugs differently than intended and significantly increase the amount of ceftriaxone in your system. Your healthcare provider may choose to monitor your progress more closely and adjust your dosage accordingly.
 
Sulfinpyrazone (Anturane)
If you are taking both ceftriaxone and sulfinpyrazone, your body may metabolize the drugs differently than intended and significantly increase the amount of ceftriaxone in your system. Your healthcare provider may choose to monitor your progress more closely and adjust your dosage accordingly.
 
Calcium or Calcium-Containing Products
Calcium and calcium-containing products can bind to ceftriaxone and cause dangerous deposits in the lungs and kidneys. These products should not be taken with ceftriaxone or within 48 hours of stopping ceftriaxone. It is important to be aware that many different IV medications contain calcium.
 
(Ceftriaxone Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;