Ceftriaxone Side Effects

Most people tolerate ceftriaxone well. When ceftriaxone side effects do occur, they are mostly minor and require little or no treatment by a healthcare provider. Common side effects of ceftriaxone include diarrhea; an increase in liver enzymes; and pain, warmth, and/or minor swelling at the injection site. Serious side effects include blood in stools, unexplained bleeding or bruising, and difficulty breathing or swallowing.

Ceftriaxone Side Effects: An Introduction

As with any medicine, there are possible side effects with ceftriaxone (Rocephin®), but not everyone who takes ceftriaxone will experience side effects. In fact, most people tolerate ceftriaxone well. When side effects do occur, in most cases they are minor, meaning they require no treatment or are easily treated by your healthcare provider.
 
(The side effects discussed below are not a complete list of side effects reported with this drug. Your healthcare provider can discuss a more complete list of ceftriaxone side effects with you.)
 

Common Ceftriaxone Side Effects

Ceftriaxone has been studied extensively in clinical trials, with thousands of people worldwide having been evaluated. In these studies, side effects are always documented and compared to people not taking the medicine. The most common side effects with ceftriaxone (occurring in either adults or children) included:
 
  • Pain, warmth, and/or minor swelling at injection site -- up to 17 percent
  • Unexplained rash -- up to 1.7 percent
  • Diarrhea -- up to 2.7 percent
  • Increase in liver enzymes -- up to 3.3 percent.
     

Possible Serious Ceftriaxone Side Effects

There are a number of side effects that can occur with ceftriaxone that indicate something serious. If you experience any of these side effects, stop taking the ceftriaxone and call your healthcare provider. These side effects include, but are not limited to:
 
  • Hives
  • Severe or watery diarrhea
  • Blood in stools
  • Throat or mouth sores
  • Unexplained bleeding or bruising
  • Severe rash
  • Itching
  • Wheezing
  • Difficulty breathing or swallowing
  • Swelling of the throat
  • Peeling of skin.
     
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