The two most common ceftriaxone uses are treating bacterial infections and preventing infection during surgery. Ceftriaxone is commonly used to treat things like skin infections, bone infections (osteomyelitis), and middle ear infections (otitis media). Ceftriaxone is not effective against viral infections. Off-label ceftriaxone uses include treating Lyme disease, epididymitis, and shigellosis.
Ceftriaxone may be used to treat a number of other bacterial infections. It may be substituted in place of penicillin to treat common infections in people who are allergic to penicillin. It should be noted that there is a small chance that people who are allergic to penicillin will also be allergic to ceftriaxone or other cephalosporins.
Ceftriaxone is not effective against any infection caused by a virus, such as the flu, stomach flu, or common cold.