Cipro Drug Interactions
Iron can bind to Cipro in the digestive tract, reducing the amount that is absorbed into the bloodstream. You should take your Cipro dose at least two hours before or six hours after taking any iron supplements to help minimize this interaction.
In general, Cipro should be used with caution when combined with any other medications that can cause QT prolongation (a certain change in the heart rhythm). Doing so may increase the risk for a life-threatening arrhythmia. Talk to your healthcare provider about this interaction if you take any QT-prolonging medications.
Cipro may increase the amount of methotrexate in your blood, increasing your risk for potentially serious side effects. If you take these medications together, your healthcare provider may need to monitor you closely for methotrexate toxicity.
Cipro may decrease the amount of mycophenolate in your blood, potentially decreasing its effectiveness. If you take these medications together, your healthcare provider may need to monitor you more closely to make sure mycophenolate is working for you.
There have been reports of seizures in clinical trials when NSAIDs where given in combination with high doses of Cipro. Check with your healthcare provider before taking Cipro with an NSAID.
P-glycoprotein (Pgp) is a protein found in the body. One of its roles is to help remove substances, such as medications, from the body. Cipro is one of the medications partly removed from the body by Pgp. Certain other medications are Pgp inducers; this means that they increase the action of Pgp.
Taking Cipro with a Pgp inducer may decrease the amount of Cipro in your blood, potentially making it less effective. Your healthcare provider may need to monitor you more closely if you take Cipro with a Pgp inducer, to make sure your infection is completely treated.