Cipro Drug Interactions
P-glycoprotein (Pgp) is a protein found in the body. One of its roles is to help remove substances, such as medications, from the body. Cipro is one of the medications partly removed from the body by Pgp. Certain other medications are Pgp inhibitors; this means that they decrease the action of Pgp.
Taking Cipro with a Pgp inhibitor may increase the amount of Cipro in your blood, potentially increasing your risk for side effects. Your healthcare provider may need to monitor you more closely if you take Cipro with a Pgp inhibitor.
Cipro may increase the amount of pentoxifylline in your body, potentially increasing your risk for pentoxifylline side effects, such as headaches. Let your healthcare provider know if you develop bothersome headaches if you are taking these medications together.
Cipro may decrease or increase the amount of phenytoin in your body, potentially making phenytoin less effective or increasing your risk for side effects. Your risk for seizures may also be increased. Talk to your healthcare provider about this interaction if you take phenytoin.
Taking probenecid with Cipro may increase the amount of Cipro in your blood, increasing your risk for side effects. Be especially watchful for Cipro side effects if you take these medications together.
Quinapril can bind to Cipro in the digestive tract, preventing it from being absorbed into the bloodstream. Separate your Cipro dose and quinapril by at least two hours to help minimize the chance of this interaction.