Drug Interactions With Clarithromycin

More Information on Interactions With Clarithromycin

The following sections explain in detail the potentially negative interactions that can occur when clarithromycin is combined with any of the drugs listed above.
 
Carbamazepine
Clarithromycin may increase the level of carbamazepine in your blood, perhaps increasing your chance for side effects of carbamazepine. Your healthcare provider may want to monitor the level of carbamazepine in your blood if you are taking both of these medications.
 
Certain Benzodiazepines
Clarithromycin may increase the level of some (but not all) benzodiazepines in the blood, increasing the risk of side effects. Check with your healthcare provider before taking these medications together.
 
Colchicine
Clarithromycin can increase the level of colchicine in your blood, potentially increasing your risk of colchicine toxicity (including death). Do not take these medications together without your healthcare provider's approval and supervision. People with poor liver or kidney function should never take colchicine with clarithromycin.
 
Digoxin
Clarithromycin may increase the level of digoxin in your blood, perhaps increasing your chance for side effects of digoxin. Your healthcare provider may want to monitor the level of digoxin in your blood if you are taking both of these medications.
 
Ergot Medications
Clarithromycin increases the risk of toxicity from ergot medications. In general, clarithromycin and ergot medications should not be combined.
 
HIV/AIDS Medications
Clarithromycin may interact with some HIV or AIDS medications. Make sure to check with your healthcare provider before combining clarithromycin with a medication for HIV or AIDS.
 
Phosphodiesterase Type 5 Inhibitors (PDE5 Inhibitors)
Clarithromycin may increase the level of PDE5 inhibitors in the blood, possibly increasing the risk of side effects. Check with your healthcare provider before taking these medications together. A lower dose of your PDE5 inhibitor may be recommended, or you may be instructed to avoid taking your PDE5 inhibitor while on clarithromycin.
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