Drug Interactions With Levofloxacin

Levofloxacin Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when levofloxacin is combined with any of the drugs listed above.
 
Aluminum, Calcium or Magnesium Antacids
Aluminum, calcium, and magnesium can bind to levofloxacin in the digestive tract, preventing it from being absorbed into the bloodstream. Separate your levofloxacin dose and any products that contain aluminum, calcium, or magnesium by as much time as possible (by at least two hours).
 
Certain Arrhythmia Medications
Combining levofloxacin with certain arrhythmia medications can increase the risk of a dangerous change in heart rhythm known as QT prolongation. Check with your healthcare provider before taking these medications together.
 
Corticosteroids
Corticosteroids seem to increase the risk of tendon rupture due to levofloxacin. If your healthcare provider recommends taking levofloxacin with a corticosteroid, be sure to watch for any signs of tendon rupture (such as pain or tenderness).
 
Diabetes Medications
There have been reports of changes in blood sugar (both high and low) in people taking diabetes medications and levofloxacin together. Your healthcare provider may recommend that you check your blood sugar more often while taking levofloxacin.
 
Didanosine
Some forms of didanosine can bind to levofloxacin in the digestive tract, preventing it from being absorbed into the bloodstream. Separate your levofloxacin dose and didanosine by as much time as possible (by at least two hours). Not all forms of didanosine interact with levofloxacin, so be sure to ask your pharmacist about this possible interaction with your particular didanosine product.
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Levofloxacin Medication Information

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