Drug Interactions With Levofloxacin

There are a number of medications that may cause drug interactions with levofloxacin, including corticosteroids, diabetes medicines, NSAIDs, and certain antacids. Some of these interactions can prevent the antibiotic from being absorbed into the bloodstream, while others can cause problems such as tendon rupture, or changes in blood sugar. To reduce the risk of levofloxacin interactions, be sure to tell your healthcare provider about your current medications.

An Overview of Levofloxacin Drug Interactions

Levofloxacin (Levaquin®) can potentially interact with a few other medications. Some of these medicines that may lead to levofloxacin interactions include:
  • Aluminum, calcium, or magnesium antacids (Alternagel®, Gaviscon®, Maalox®, Mylanta®, Tums®, and many others)
  • Certain arrhythmia medications, including:



  • Corticosteroids, such as:


    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)




The Dirty, Messy Part of BPH

Levofloxacin Medication Information

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