Bacteria Home > Precautions and Warnings With Cefprozil

To minimize your risk of potentially serious problems while using cefprozil, many safety precautions are in place. For instance, this antibiotic has warnings related to possible allergies, particularly if you have allergies to cephalosporin or penicillin antibiotics. Other risks include potential drug interactions and safety concerns for people who have kidney disease.


What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking cefprozil (Cefzil®) if you have:
  • Kidney disease, such as kidney failure (renal failure)
  • An allergy to cephalosporin or penicillin antibiotics
  • Phenylketonuria
  • Any other allergies, including to foods, dyes, or preservatives.
In addition, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Cefprozil Precautions and Warnings

Some warnings and precautions to be aware of prior to using this medication include the following:
  • Cefprozil contains an antibiotic that belongs to the cephalosporin group of antibiotics, which are related to penicillin antibiotics. Some people who are allergic to penicillin will also be allergic to cefprozil. An allergic reaction can be quite dangerous. Let your healthcare provider know immediately if you notice any signs of such a reaction, such as:
    • A rash
    • Itching
    • Hives
    • Wheezing
    • Swelling of the mouth or lips
    • Difficulty breathing.
  • Make sure your healthcare provider knows if you have kidney disease, as the kidneys excrete cefprozil from the body. If your kidneys are not functioning well, you will need a lower and/or less-frequent dosage.
  • Let your healthcare provider know if you experience bloody or watery diarrhea. While diarrhea is a common side effect of cefprozil, bloody or watery diarrhea may be a sign of a serious reaction to the drug that can occur when certain bacteria (Clostridium difficile) overgrow in the colon. This severe reaction can occur long after you stop using cefprozil and can be life-threatening.
  • Cefprozil oral suspension (liquid) contains 28 mg of phenylalanine per teaspoonful (per 5 mL). This is important for people with phenylketonuria, who must monitor and limit their phenylalanine intake.
  • Antibiotics can sometimes cause yeast infections, as they can get rid of "good" bacteria that help protect against yeast infections. Let your healthcare provider know if you develop a vaginal yeast infection or thrush (a yeast infection of the mouth) during treatment.
  • Cefprozil should not be used to treat viruses, such as the common cold or the flu. This drug is completely ineffective for treating viruses, and such use can lead to bacterial resistance.
  • Cefprozil is a pregnancy Category B medication. This means that it is probably safe for use during pregnancy, although the full risks are currently unknown. Talk to your healthcare provider about the risks and benefits of using this medicine when pregnant (see Cefzil and Pregnancy for more information).
  • This medication passes through breast milk. Therefore, if you are breastfeeding or plan to start, talk to your healthcare provider before beginning treatment (see Cefzil and Breastfeeding for more information).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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