Mefoxin and Pregnancy
In clinical studies, Mefoxin (cefoxitin) did not appear to cause problems when given to pregnant rats and mice. Although no studies have been done on using this drug in pregnant women, it appears that Mefoxin is probably safe for use during pregnancy. However, make sure to talk to your healthcare provider about the risks in your particular situation.
Can Pregnant Women Receive Mefoxin?Mefoxin® (cefoxitin) is a prescription antibiotic given intravenously (by IV). This product is usually considered safe for use during pregnancy.
What Is Pregnancy Category B?The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Mefoxin is classified as a pregnancy Category B medication.
Pregnancy Category B is given to medicines that have not been adequately studied in pregnant humans but do not appear to cause harm to the fetus in animal studies. Medications that have been shown to be safe for use in pregnancy in humans but have caused problems in laboratory animals are also given a Category B rating.
Mefoxin was given a pregnancy Category B rating because studies in pregnant rats and mice did not appear to cause any problems, even when the drug was given in doses equivalent to 7.5 times the human dose. In rabbits, however, the drug was fatal to both mother and fetal rabbits, but this is likely due to the extreme sensitivity of rabbits to antibiotics.
However, it is important to note that animals do not always respond to medicines in the same way that humans do. Therefore, a pregnancy Category B medicine should be given to a pregnant woman only if her healthcare provider believes that the benefits to the woman outweigh any possible risks to her unborn child.
Although the drug has not been systematically studied in pregnant women, it is known that Mefoxin crosses the placenta. However, cephalosporins (like Mefoxin) are generally safe for use during pregnancy.
Mefoxin is sometimes given during a cesarean section (C-section), right after the cord is clamped (this helps prevent exposing the baby to the drug). It does pass through breast milk, but in low amounts (see Mefoxin and Breastfeeding).