Precautions and Warnings With Moxifloxacin

Specific Warnings and Precautions for Moxifloxacin

Some warnings and precautions to be aware of with moxifloxacin include the following:
  • Moxifloxacin and other, similar antibiotics can cause rupture of tendons, including shoulder, hand, or Achilles tendons. This can be disabling and can require surgical repair. Let your healthcare provider know right away if you develop tendon soreness or pain. Do not exercise until your healthcare provider makes sure you do not have a ruptured tendon. This problem can occur while you are taking the medication or even months later.


  • People who are over 60 years old, who have had liver, lung, or heart transplants, or who take corticosteroid drugs are at an increased risk for tendon rupture. People with kidney disease, those who exercise vigorously, and people with rheumatoid arthritis (or other tendon disorders) may also be at a higher risk. 


  • This medication can cause a change in the heart rhythm known as QT prolongation. This can be dangerous and may be more common in people with low blood potassium. You are also at higher risk for this problem if you take other medications that can cause QT prolongation or if you have long QT syndrome.


  • Moxifloxacin (as well as all other fluoroquinolone antibiotics) can cause worsening of myasthenia gravis symptoms, such as muscle weakness and breathing problems. This is a serious occurrence, which can be life-threatening. In severe cases, this can result in the need to be put on a ventilator, or even death. Moxifloxacin should be avoided in people with a known history of myasthenia gravis


  • Moxifloxacin can cause severe allergic reactions. Seek immediate medical attention if you develop any signs of an allergic reaction, such as:
    • A rash or hives
    • Itching
    • Swelling of the lips or throat
    • Wheezing
    • Difficulty breathing.
  • Moxifloxacin can cause central nervous system problems, such as:
Certain conditions (including epilepsy, cerebral arteriosclerosis, and kidney disease) may increase the risk of these problems.
  • Let your healthcare provider know if you experience bloody or watery diarrhea. While diarrhea is a common side effect of moxifloxacin, bloody or watery diarrhea may be a sign of a serious reaction to moxifloxacin that can occur when certain bacteria (Clostridium difficile) overgrow in the colon. This severe reaction can occur long after you stop taking the drug and can be life-threatening.
  • Moxifloxacin can cause nerve problems. Be sure to tell your healthcare provider if you develop any unusual sensations (such as numbness, burning, or tingling) while taking it.
  • This medication can cause muscle, joint, or tendon problems in children. It is not approved for any use in children.
  • Overuse of antibiotics increases the risk for developing antibiotic-resistant bacteria. Your healthcare provider should prescribe antibiotics only when necessary (and only to treat bacterial infections). Antibiotics are not effective for treating viral infections, such as the common cold or the flu.
  • Sometimes, antibiotics can cause yeast infections, since they can get rid of "good" bacteria that help protect against yeast infections. Let your healthcare provider know if you develop a vaginal yeast infection or thrush (a yeast infection of the mouth) while taking moxifloxacin.
  • It is very important that you take moxifloxacin exactly as prescribed. Skipping doses or stopping the drug too early (even if you feel better) can lead to bacterial resistance to moxifloxacin.
  • Moxifloxacin can interact with other medications (see Drug Interactions With Moxifloxacin).
  • Moxifloxacin is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not known. Talk to your healthcare provider about the risks and benefits of using the drug when pregnant (see Avelox and Pregnancy for more information).
  • It is unknown if moxifloxacin passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to using the drug (see Avelox and Breastfeeding for more information).

Moxifloxacin Hydrochloride Information

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