Drug Interactions With Norfloxacin

Norfloxacin may increase the level of tacrine in the bloodstream, potentially causing serious side effects. Check with your healthcare provider before taking these medications together.
Norfloxacin may increase the level of theophylline in your blood, potentially increasing your risk for seizures or other serious side effects. If you take these medications together, your healthcare provider may want to monitor the level of theophylline in your blood. You may need a lower theophylline dosage.
Norfloxacin may increase the amount of tizanidine in your blood, increasing your risk for side effects, such as sedation or low blood pressure (hypotension). If you take these medications together, you may need to be watchful for increased tizanidine side effects.
Typhoid Vaccine
Antibiotics, including norfloxacin, may decrease the effectiveness of the typhoid vaccine. This interaction only occurs with the oral typhoid vaccine. Therefore, it is generally recommended that the oral typhoid vaccine be postponed until at least 24 hours after the final norfloxacin dose.
Vitamins With Aluminum, Magnesium, Calcium, Zinc, or Iron
Aluminum, magnesium, zinc, calcium, and iron can bind to norfloxacin in the digestive tract, preventing it from being fully absorbed into the bloodstream. You should take your norfloxacin dose at least two hours before or six hours after taking any vitamins that contain aluminum, magnesium, calcium, zinc, or iron.
Norfloxacin may increase the effects of warfarin in the body, potentially increasing your risk for bleeding. If you take norfloxacin with warfarin, your healthcare provider may need to monitor you more closely and adjust your warfarin dosage if needed.
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Norfloxacin Drug Information

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