Drug Interactions With Ofloxacin

More Detail on Drug Interactions With Ofloxacin

The following sections explain in detail the potentially negative reactions that can occur when ofloxacin is combined with any of the drugs listed above.
 
Aluminum, Calcium, or Magnesium Antacids
Aluminum, calcium, and magnesium can bind to ofloxacin in the digestive tract, preventing it from being fully absorbed into the bloodstream. You should take your ofloxacin dosage at least two hours before or six hours after any products containing aluminum, calcium, or magnesium.
 
Aspirin
Certain aspirin products may bind to ofloxacin in the digestive tract, preventing it from being fully absorbed into the bloodstream. You should take your ofloxacin dose at least two hours before or six hours after buffered aspirin. This interaction is not likely to occur with enteric-coated or regular aspirin.
 
Betaxolol
Ofloxacin may increase the amount of betaxolol in the bloodstream, potentially increasing your risk for side effects. If you currently take betaxolol, talk to your healthcare provider about this drug interaction before taking ofloxacin.
 
Caffeine
Ofloxacin may reduce the body's ability to clear caffeine, potentially increasing its effects. Therefore, it may be a good idea to limit your caffeine intake while taking ofloxacin. Keep in mind that many foods and beverages contain caffeine, such as coffee, tea, and chocolate.
 
Certain Antipsychotics
Ofloxacin may increase the amount of certain antipsychotic medications in the bloodstream, potentially increasing your risk for side effects. This interaction does not occur with all antipsychotic drugs. Talk to your healthcare provider about this before taking ofloxacin.
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