Drug Interactions With Ofloxacin

Clomipramine
Ofloxacin may increase the amount of clomipramine in the bloodstream, potentially increasing your risk for side effects. If you currently take clomipramine, talk to your healthcare provider about this drug interaction before taking ofloxacin.
 
Corticosteroids
Taking ofloxacin with corticosteroids may increase the risk of tendon problems, including tendon rupture. Older adults appear to be at an even higher risk for this reaction. If you take ofloxacin with a corticosteroid, be sure to watch for any signs of tendon problems, such as tendon or joint pain or tenderness. Report any such problems immediately to your healthcare provider.
 
Cyclobenzaprine
Ofloxacin may increase the amount of cyclobenzaprine in the bloodstream, potentially increasing your risk for side effects. If you currently take cyclobenzaprine, talk to your healthcare provider about this drug interaction before taking ofloxacin.
 
Didanosine
Some forms of didanosine can bind to ofloxacin in the digestive tract, preventing it from being completely absorbed into the bloodstream. You should take your ofloxacin dose at least two hours before or six hours after didanosine. Not all forms of didanosine interact with ofloxacin, so ask your pharmacist about this possible interaction with your particular didanosine product.
 
Duloxetine
Ofloxacin may increase the amount of duloxetine in the bloodstream, potentially increasing your risk for side effects. If you currently take duloxetine, talk to your healthcare provider about this drug interaction before taking ofloxacin.
 
Flutamide
Ofloxacin may increase the level of flutamide in the bloodstream, potentially increasing your risk for side effects. If you take these medications together, your healthcare provider may choose to monitor you more closely.
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