Drug Interactions With Ofloxacin

Fluvoxamine
Ofloxacin may increase the amount of fluvoxamine in the bloodstream, potentially increasing your risk for side effects or low blood pressure. If you take fluvoxamine, talk to your healthcare provider about this drug interaction before taking ofloxacin.
 
Guanabenz
Ofloxacin may increase the amount of guanabenz in the bloodstream, potentially increasing your risk for side effects. If you take these medications together, your healthcare provider may choose to monitor you more closely.
 
Insulin
There have been reports of changes in blood sugar (both low and high) in people taking fluoroquinolones such as ofloxacin. Taking ofloxacin with insulin may increase your risk for these blood sugar problems. If you currently take insulin, your healthcare provider may recommend that you check your blood sugar more often while taking ofloxacin.
 
Iron Supplements
Iron can bind to ofloxacin in the digestive tract, reducing the amount absorbed into the bloodstream. You should take your ofloxacin dose at least two hours before or six hours after any iron supplements to help minimize this interaction.
 
QT-Prolonging Medications
In general, ofloxacin should be used with caution in combination with any other medications that can cause QT prolongation (a certain change in the heart rhythm), because of the risk of a life-threatening arrhythmia. Talk to your healthcare provider about this if you take any QT-prolonging medications.
 
Mexiletine
Ofloxacin may increase the amount of mexiletine in your body, potentially increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely if you take these medications together.
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