Drug Interactions With Ofloxacin

Mirtazapine
Ofloxacin may increase the amount of mirtazapine in your body, potentially increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely for mirtazapine side effects if you take these medications together.
 
Mycophenolate
Ofloxacin may decrease the amount of mycophenolate in your blood, potentially decreasing its effectiveness. If you take these medications together, your healthcare provider may need to monitor you more closely to make sure mycophenolate is working for you.
 
NSAIDs
Taking an NSAID with ofloxacin may increase the risk for central nervous system stimulation, including possible seizures. Talk to your healthcare provider before combining these medications.
 
Probenecid
Taking probenecid with ofloxacin may increase the levels of ofloxacin in your bloodstream, increasing your risk for side effects. Be especially watchful for ofloxacin side effects if you take these medications together.
 
Propranolol
Ofloxacin may increase the amount of propranolol in your body, increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely for propranolol side effects if you take these medications together.
 
Quinapril
Quinapril can bind to ofloxacin in the digestive tract, preventing it from being fully absorbed into the bloodstream. Separate your ofloxacin and quinapril doses by at least two hours to help minimize the chance of this drug interaction.
 
Ramelteon
Ofloxacin may increase the amount of ramelteon in your body, potentially increasing your risk for side effects. If you currently take ramelteon, talk to your healthcare provider about this interaction before you take ofloxacin.
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