Drug Interactions With Ofloxacin

Rasagiline
Ofloxacin may increase the amount of rasagiline in your bloodstream, increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely for rasagiline side effects if you take these medications together.
 
Ropinirole
Ofloxacin may increase the amount of ropinirole in your body, increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely for ropinirole side effects if you take these medications together.
 
Sevelamer
Sevelamer can bind to ofloxacin in the digestive tract, decreasing the amount that is absorbed into the bloodstream. You should take ofloxacin at least one hour before or three hours after sevelamer.
 
Sucralfate
Sucralfate can bind to ofloxacin in the digestive tract, decreasing the amount absorbed into the bloodstream. You should take your ofloxacin dose at least two hours before or six hours after sucralfate to help minimize the risk of this interaction.
 
Sulfonylureas
There have been reports of changes in blood sugar (both low and high) in people taking sulfonylureas with fluoroquinolones such as ofloxacin. Low blood sugar (hypoglycemia) may be more likely within the first couple of days of ofloxacin treatment, while high blood sugar (hyperglycemia) may be more likely after several days.
 
If you currently take a sulfonylurea, your healthcare provider may recommend that you check your blood sugar more often while taking ofloxacin.
 
Theophylline
Ofloxacin may increase the level of theophylline in your blood, potentially increasing your risk for serious side effects, including seizures. If you take these medications together, your healthcare provider may want to monitor the level of theophylline in your blood, and you may need a lower dose.
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