Drug Interactions With Ofloxacin

Ofloxacin may increase the amount of tizanidine in your blood, increasing your risk for side effects, such as sedation or low blood pressure (hypotension). If you take these medications together, you may need to be watchful for increased tizanidine side effects.
Typhoid Vaccine
Antibiotics, including ofloxacin, may decrease the effectiveness of the typhoid vaccine. However, this interaction only occurs with the oral typhoid vaccine. It is generally recommended that the oral typhoid vaccine be postponed until at least 24 hours after the final ofloxacin dose.
Vitamins With Aluminum, Magnesium, Calcium, Zinc, or Iron
Aluminum, magnesium, zinc, calcium, and iron can bind to ofloxacin in the digestive tract, preventing it from being fully absorbed into the bloodstream. You should take your ofloxacin dose at least two hours before or six hours after any vitamins containing aluminum, magnesium, calcium, zinc, or iron.
Ofloxacin may increase the effects of warfarin in the body, potentially increasing your risk of bleeding. If you take these drugs together, your healthcare provider may need to monitor you more closely and adjust your warfarin dose if needed.

Final Thoughts

It is possible that not all ofloxacin drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific interactions that may apply to you.
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