Important Information for Your Healthcare ProviderYou should talk with your healthcare provider prior to taking this medication if you have:
- Kidney disease, such as kidney failure (renal failure)
- Liver disease, such as hepatitis, cirrhosis, or liver failure
- Tendon or joint problems
- Nerve problems, such as neuropathy
- A history of seizures or epilepsy
- An irregular heartbeat or a heart rhythm problem known as long QT syndrome, or have family members with these problems
- Cerebral arteriosclerosis (hardening and thickening of the arteries of the brain)
- Any allergies, including to medications, foods, dyes, or preservatives
- Myasthenia gravis.
Also, let your healthcare provider know if you are:
- Pregnant or thinking of becoming pregnant (see Ofloxacin and Pregnancy)
- Breastfeeding (see Ofloxacin and Breastfeeding).
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Ofloxacin to learn more, including information on who should not take the drug.)
How Does Ofloxacin Work?Like other quinolones, ofloxacin works by killing certain bacteria that cause infections. Specifically, it interferes with two bacterial enzymes called topoisomerase IV and DNA gyrase. These enzymes are needed by the bacteria to copy and repair DNA, important steps for the bacteria to multiply.