Ofloxacin Side Effects

Common Side Effects

Ofloxacin has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people taking ofloxacin were documented and then compared to those that occurred in a similar group of people taking either a placebo (a "sugar pill" with no active ingredients) or another antibiotic.
The different forms of ofloxacin may have significantly different side effects. In clinical studies, the most commonly reported side effects of oral ofloxacin included:
  • Nausea -- in up to 10 percent of people
  • Headache -- up to 9 percent
  • Insomnia -- up to 7 percent
  • External genital itching in women -- up to 6 percent
  • Vaginal inflammation or infections, such as a yeast infection -- up to 5 percent
  • Dizziness -- up to 5 percent
  • Diarrhea -- up to 4 percent
  • Vomiting -- up to 4 percent
  • Rash -- up to 1 percent
  • Itching -- up to 1 percent
  • Changes in taste sensation -- up to 1 percent.
The most commonly reported side effects of ofloxacin otic solution included:
  • Ear discomfort with use -- in up to 16.8 percent of people
  • Bitter taste -- up to 7 percent
  • Itching in the ear -- up to 4 percent
  • Ear pain -- up to 1 percent
  • Dizziness -- up to 1 percent
  • A spinning sensation (vertigo) -- up to 1 percent
  • Rash -- up to 1 percent
  • Unusual feelings of tingling, pricking, or "pins and needles" -- up to 1 percent.
The bitter taste is thought to be from the medication passing through the middle ear to the back of the mouth. It is not considered a serious side effect, and is not a reason to stop using ofloxacin otic solution.
The most commonly reported side effects with ofloxacin ophthalmic solution (the specific percentages are unknown) included:
  • Short-term eye burning or discomfort
  • Eye stinging
  • Eye itching
  • Eye redness
  • Inflammation of the eye or surrounding area
  • Feeling like something is in the eye
  • Sensitivity to light
  • Blurred vision
  • Tearing
  • Dry eyes
  • Eye pain.
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