Rifampin Side Effects

Some of the possible side effects with rifampin include heartburn, vomiting, and diarrhea. There are also some potentially serious reactions associated with rifampin, such as fever, seizures, or bloody diarrhea, which require urgent medical treatment. Because rifampin is an older medication, there is no specific information on how often certain side effects may occur.


An Introduction to Side Effects of Rifampin

As with any medicine, rifampin (Rifadin®) can cause side effects. However, not everyone who uses the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with rifampin. Your healthcare provider can discuss a more complete list with you.)

Serious Rifampin Side Effects

Some rifampin side effects may be signs of potentially serious problems, and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Lightheadedness or fainting
  • Signs of liver problems, such as:
    • Upper-right abdominal (stomach) pain
    • Dark urine
    • Light-colored stool
    • Yellowing of the skin or whites of the eyes (jaundice)
  • Severe or bloody diarrhea
  • Red or purple spots on the skin
  • Swelling of any part of the body
  • Decrease in the amount or how often you urinate
  • Blood in the urine
  • Any unusual bleeding or unexplained bruising
  • Signs of an infection, such as:
    • Fever
    • Chills
    • Body aches
  • Signs of anemia, such as:
    • Unusual weakness
    • Lack of energy
    • Pale skin
    • Lightheadedness
    • Feeling short of breath
  • Seeing or hearing things that are not real or losing touch with reality
  • Changes in your mood or behavior
  • Chest pain
  • Pain, warmth, or swelling in the lower leg
  • Severe headache
  • Difficulty walking or speaking
  • Seizures
  • Signs of an allergic reaction to rifampin, such as:
    • An unexplained rash
    • Hives
    • Blisters on the skin or in the mouth
    • Unexplained swelling, especially of the mouth, lips, or throat
    • Wheezing
    • Difficulty breathing or swallowing.

Rifampin Antibiotic Information

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