Drug Interactions With Sulfamethoxazole/Trimethoprim

Indomethacin
Indomethacin may increase the level of sulfamethoxazole (one of the active ingredients of sulfamethoxazole/trimethoprim) in the blood. Be sure to check with your healthcare provider before combining sulfamethoxazole/trimethoprim with indomethacin.
 
Leucovorin or Levoleucovorin
Leucovorin or levoleucovorin may decrease the effectiveness of sulfamethoxazole/trimethoprim. In general, these medications should not be used together unless absolutely necessary.
 
Methotrexate
Sulfamethoxazole/trimethoprim can increase the level of methotrexate in the blood, increasing the risk of dangerous side effects of methotrexate. In general, these medications should not be used together.
 
Oral Diabetes Medications
Sulfamethoxazole/trimethoprim may increase the risk of low blood sugar (hypoglycemia) due to some oral diabetes medications. Check with your healthcare provider before combining sulfamethoxazole/trimethoprim with an oral diabetes medication. You may need to monitor your blood sugar more closely.
 
Oral Typhoid Vaccine
Antibiotics (including sulfamethoxazole/trimethoprim) may decrease the effectiveness of the oral typhoid vaccine. If you are taking sulfamethoxazole/trimethoprim, your oral typhoid vaccine may need to be postponed for at least a day after your last dose of sulfamethoxazole/trimethoprim.
 
Phenytoin
Sulfamethoxazole/trimethoprim can increase the level of phenytoin in your blood, increasing the risk of phenytoin side effects. Your healthcare provider may want to monitor the level of phenytoin in your blood and may need to adjust your phenytoin dosage.
 
Procainamide
Sulfamethoxazole/trimethoprim increases the level of procainamide in the blood, increasing your risk of dangerous side effects of procainamide. Check with your healthcare provider before taking these medications together.
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Sulfamethoxazole Trimethoprim Information

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