Drug Interactions With Sulfamethoxazole/Trimethoprim

It is possible that taking sulfamethoxazole/trimethoprim with pyrimethamine might increase the risk of anemia. Check with your healthcare provider before taking pyrimethamine with sulfamethoxazole/trimethoprim.
Thiazide Diuretics
There have been reports that taking sulfamethoxazole/trimethoprim with a thiazide diuretic may increase the risk of low blood platelets. Be sure to watch for any signs of low platelets, such as easy bruising or bleeding.
Tricyclic Antidepressants
Sulfamethoxazole/trimethoprim might decrease the effectiveness of tricyclic antidepressants. Be sure to let your healthcare provider know if you think your antidepressant is not working as well as usual.
There have been reports that combining sulfamethoxazole/trimethoprim with warfarin may increase the risk of bleeding. If you take these medications together, your healthcare provider may need to monitor you more closely.

Final Thoughts

Not all sulfamethoxazole/trimethoprim drug interactions were discussed in this article. Compared to many other medications, sulfamethoxazole/trimethoprim has a high likelihood for drug interactions. Therefore, you should talk with your pharmacist or healthcare provider about any specific drug interactions that may apply to you.
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Sulfamethoxazole Trimethoprim Information

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