Drug Interactions With Sulfamethoxazole/Trimethoprim

A number of medications can cause drug interactions with sulfamethoxazole/trimethoprim, including phenytoin, ACE inhibitors, tricyclic antidepressants, and warfarin. Some interactions may reduce the effectiveness of the medications, while others can increase the drug levels in your blood, perhaps increasing your chance for side effects. To help minimize your risk of developing drug interactions, tell your healthcare provider about all other medications you are taking.

An Overview of Interactions With Sulfamethoxazole/Trimethoprim

Sulfamethoxazole/trimethoprim (Bactrim®, Bactrim® DS, Septra®, Septra® DS, Sulfatrim®) can potentially interact with numerous different medications, too many to list entirely in this article. Medicines that may lead to sulfamethoxazole/trimethoprim drug interactions include (but are not limited to):
 
  • Angiotensin-converting enzyme inhibitors (usually known as ACE inhibitors), including:

 

 

 

 

 

 

 

 


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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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