Precautions and Warnings With Sulfamethoxazole/Trimethoprim

Make sure to talk to your healthcare provider about the precautions and warnings with sulfamethoxazole/trimethoprim to help ensure safe use of the drug. The antibiotic can worsen certain medical conditions, so tell your healthcare provider about all existing conditions you have before starting treatment. You should not take this medication if you are pregnant or breastfeeding, have significant liver disease, or have severe kidney problems.

What Should I Tell My Healthcare Provider Before Taking Sulfamethoxazole/Trimethoprim?

You should talk with your healthcare provider prior to taking sulfamethoxazole/trimethoprim (Bactrim®, Bactrim® DS, Septra®, Septra® DS, Sulfatrim®) if you have:
 
  • Anemia
  • Asthma
  • Glucose-6-phosphate dehydrogenase deficiency
  • HIV or AIDS
  • Kidney disease, such as kidney failure (renal failure)
  • Liver disease, such as liver failure, cirrhosis, or hepatitis
  • A folic acid deficiency
  • Phenylketonuria (PKU)
  • A thyroid disorder
  • Porphyria
  • Any other allergies, including allergies to food, dyes, or preservatives.
     
Also, let your healthcare provider know if you are:
 
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
     
Make sure to tell your healthcare provider about all other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
 

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(Precautions and Warnings With Sulfamethoxazole/Trimethoprim Continued: Page 2)
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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